APPL2 and CRBN

  • Number of citations of the paper that reports this interaction (PubMedID 25814554)
  • 22
  • Data Source:
  • BioGRID (two hybrid)

APPL2

CRBN

Description adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 cereblon
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Amyotrophic lateral sclerosis (sporadic) ( 24529757)
  • Basophil percentage of granulocytes ( 27863252)
  • Basophil percentage of white cells ( 27863252)
  • Immune response to smallpox vaccine (IL-6) ( 22542470)
  • Knee osteoarthritis ( 27696742)
  • Restless legs syndrome ( 29029846)
  • White blood cell count (basophil) ( 29403010 27863252)
  • White matter integrity ( 23218918)
Interacting Genes 27 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RPL36 RUVBL2 SUV39H2 TINF2 TSC1 33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID 55198 51185
HPRD ID 06945 16750
Ensembl ID ENSG00000136044 ENSG00000113851
Uniprot IDs Q8NEU8 Q96SW2
PDB IDs 4H8S 5C5B 4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
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