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MTDH and ERCC2
Number of citations of the paper that reports this interaction (PubMedID
22199357
)
28
Data Source:
BioGRID
(unspecified method)
MTDH
ERCC2
Description
metadherin
ERCC excision repair 2, TFIIH core complex helicase subunit
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Bicellular Tight Junction
Integral Component Of Membrane
Apical Plasma Membrane
Nuclear Body
Nuclear Membrane
Intercellular Canaliculus
Perinuclear Region Of Cytoplasm
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Cytoplasm
Spindle
Cytosol
CAK-ERCC2 Complex
MMXD Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Double-stranded RNA Binding
Protein Binding
NF-kappaB Binding
DNA Helicase Activity
Damaged DNA Binding
Protein Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Protein Binding, Bridging
5'-3' DNA Helicase Activity
Metal Ion Binding
Protein N-terminus Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Autophagy
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Angiogenesis
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Bicellular Tight Junction Assembly
Positive Regulation Of Nucleic Acid-templated Transcription
Regulation Of Mitotic Recombination
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nucleotide-excision Repair, DNA Duplex Unwinding
Response To Hypoxia
In Utero Embryonic Development
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Apoptotic Process
Response To Oxidative Stress
Chromosome Segregation
Aging
Cell Proliferation
Response To UV
UV Protection
Post-embryonic Development
Viral Process
Spinal Cord Development
Extracellular Matrix Organization
Bone Mineralization
Central Nervous System Myelin Formation
Nucleotide-excision Repair, DNA Incision
Multicellular Organism Growth
Hair Cell Differentiation
Embryonic Cleavage
Erythrocyte Maturation
Positive Regulation Of DNA Binding
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Recombination
Embryonic Organ Development
Hair Follicle Maturation
Hematopoietic Stem Cell Differentiation
Global Genome Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
Cytosolic iron-sulfur cluster assembly
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Mean corpuscular hemoglobin (
29403010
)
Migraine (
20802479
)
nicotine metabolite ratio in current smokers (
27488534
)
Plasma parathyroid hormone levels (
30134803
)
Red cell distribution width (
27863252
28957414
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Lung Cancer (DNA repair capacity) (
23108145
)
Interacting Genes
174 interacting genes:
ABCA12
ABCC3
ABTB1
ACTN1
ADCK2
ADGRA2
AGAP3
ALOX5
ANKRD13D
ANKRD26P1
ANPEP
ARNT2
ARRDC1
AXL
BCAS3
BCS1L
CAPN2
CARD8
CCL20
CCN2
CCNDBP1
CCT4
CD109
CD22
CDC14B
CENPJ
CEP162
CLCN7
CLDN2
CLMN
COL13A1
COL4A4
COL6A1
CPT2
CRIM1
CSNK2A1
CTSB
CUL7
CUL9
CYFIP2
CYP27A1
CYP4V2
DMTF1
DNAH5
DOCK2
DOP1B
DSP
DUSP5
ECE1
EGFR
EGR1
ELN
EML1
EPHB1
EPHX2
ERCC2
ERICH6B
ESAM
FAM184A
FANCI
FASN
FCGRT
FLNA
FLNC
FN1
GHDC
GLG1
GRID1
HACE1
HERC5
HP1BP3
HSPG2
ICA1L
IFT46
IKBKB
IL17RA
IL2RB
IPO9
IRS2
ITGB5
ITPR3
JADE3
JAG1
KCNH1
KCNQ5
KDM6A
KMT2B
LAMA5
LDLRAD2
LOXL4
LRIG3
LRP1
LRP5
MAP3K12
MCM6
MEGF11
METTL3
MLPH
MMP2
MNT
MRC2
MRPL39
MYH9
MYL5
NEB
NEO1
NFKB2
NOTCH3
NPC1
NPR1
NUP210
NXF4
OBSCN
OGT
OR8G5
OSMR
PCCB
PCDH7
PDCD11
PKN1
PLAT
PLD2
PLEC
PLEKHO2
PLXNA3
PPFIA2
PRICKLE4
PSIP1
PTHLH
PWP2
RAB24
RGS13
RIN1
RIPK1
RNF123
RNF213
RSPO3
RYR1
SDK1
SELENOI
SEZ6L2
SGSM2
SH2B2
SIAE
SLC22A18AS
SLC38A4
SPEF2
SPRED2
SPTBN5
SQSTM1
SSH3
STEAP3
STK25
STXBP1
SYNE1
TACR2
TBC1D2B
TBCD
TCIRG1
TEP1
THBS1
THSD4
TINAGL1
TNS2
TOPORS
TRAPPC12
TRPC4AP
TUBB3
VIM
WDFY2
WDR78
WNK2
ZNF559
ZXDC
16 interacting genes:
AR
CDK1
CDK7
ERCC3
ERCC5
GTF2H1
GTF2H2
GTF2H2C_2
GTF2H3
HERC5
MNAT1
MTDH
RAD51
RAD52
TP53
TRIM25
Entrez ID
92140
2068
HPRD ID
17459
00530
Ensembl ID
ENSG00000147649
ENSG00000104884
Uniprot IDs
A0A024R9D2
Q86UE4
P18074
PDB IDs
4QMG
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
Enriched GO Terms of Interacting Partners
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