LRSAM1 and RNF111

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		LRSAM1	RNF111
Description		leucine rich repeat and sterile alpha motif containing 1	ring finger protein 111
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Autophagy Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		37 interacting genes: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	44 interacting genes: ACTN3 ANAPC11 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD FBN1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W
Entrez ID		90678	54778
HPRD ID		14325	09318
Ensembl ID		ENSG00000148356	ENSG00000157450
Uniprot IDs		A0A024R870 Q6UWE0	A0A024R5T5 Q6ZNA4
PDB IDs			2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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