PRC1 and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 9885575)
118

Data Source:
BioGRID (enzymatic study)

		PRC1	CCNE1
Description		protein regulator of cytokinesis 1	cyclin E1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding
	Biological Process	Mitotic Spindle Elongation Microtubule Bundle Formation Positive Regulation Of Cell Proliferation Regulation Of Cytokinesis Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Synapsis Wnt Signaling Pathway Androgen Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Localization
Pathways		RHO GTPases activate CIT	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS		Breast cancer ( 29059683 25038754) Mean platelet volume ( 27863252) Multisite chronic pain ( 31194737) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 20581827 30718926 28869590)	Bladder cancer ( 24163127 20972438) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 28135244 27841878) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458)
Interacting Genes		25 interacting genes: AKAP9 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 NDEL1 PCM1 PLK1 RACGAP1 RBM10 RPA2 SF3B2 SLAIN1 TRIM37 USHBP1 YWHAE	68 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A LATS2 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		9055	898
HPRD ID		17899	00455
Ensembl ID		ENSG00000198901	ENSG00000105173
Uniprot IDs		A0A024RC67 O43663	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		3NRX 3NRY 4L3I 4L6Y 5KMG	1W98 5L2W
Enriched GO Terms of Interacting Partners?
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