SKAP2 and HCK

  • Number of citations of the paper that reports this interaction (PubMedID 9837776)
  • 11
  • Data Source:
  • HPRD (in vivo)

SKAP2

HCK

Description src kinase associated phosphoprotein 2 HCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Chronic venous disease ( 28374850)
  • Erosive tooth wear (severe vs non-severe) ( 29898447)
  • Erosive tooth wear (severe vs none or mild) ( 29898447)
  • FEV1 ( 30804560)
  • Lung function (FVC) ( 30804560)
  • Macular thickness ( 30535121)
  • Peak expiratory flow ( 30804560)
  • Small cell lung carcinoma ( 28604730)
  • Systemic lupus erythematosus ( 28714469)
  • Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
  • Inflammatory bowel disease ( 23128233)
  • Migraine ( 27322543)
Interacting Genes 19 interacting genes: APP BLK FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1 78 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK CBL CCR3 CD2AP CHST15 COMT CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 EGFR ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A FHL2 GOPC GRB14 HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 LETMD1 LMNA MAP4K5 MDM2 MTUS2 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TP73 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2
Entrez ID 8935 3055
HPRD ID 05558 00796
Ensembl ID ENSG00000005020 ENSG00000101336
Uniprot IDs B7Z5R3 O75563 A8K4G3 P08631
PDB IDs 3OMH 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6
Enriched GO Terms of Interacting Partners?
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