HCK and MAP4K5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		HCK	MAP4K5
Description		HCK proto-oncogene, Src family tyrosine kinase	mitogen-activated protein kinase kinase kinase kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Leukocyte Degranulation Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Intracellular Signal Transduction
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FLT3 Signaling FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 23128233) Migraine ( 27322543)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		78 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK CBL CCR3 CD2AP CHST15 COMT CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 EGFR ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A FHL2 GOPC GRB14 HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 LETMD1 LMNA MAP4K5 MDM2 MTUS2 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TP73 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2	13 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440
Entrez ID		3055	11183
HPRD ID		00796	05374
Ensembl ID		ENSG00000101336	ENSG00000012983
Uniprot IDs		A8K4G3 P08631	B3KWC4 Q9Y4K4
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6
Enriched GO Terms of Interacting Partners?
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