NAE1 and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 8626687)
29

Data Source:
HPRD (in vivo)

		NAE1	TP53BP2
Description		NEDD8 activating enzyme E1 subunit 1	tumor protein p53 binding protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Signal Transduction Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Neddylation	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs		ATP
Diseases
GWAS			Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4	64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26
Entrez ID		8883	7159
HPRD ID		04545	11803
Ensembl ID		ENSG00000159593	ENSG00000143514
Uniprot IDs		Q13564	Q13625
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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