SOCS2 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SOCS2	ARFIP2
Description		suppressor of cytokine signaling 2	ADP ribosylation factor interacting protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Identical Protein Binding Cadherin Binding Rac GTPase Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Regulation Of Cell Growth JAK-STAT Cascade Lactation Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Neuron Differentiation Negative Regulation Of JAK-STAT Cascade Phosphatidylinositol Phosphorylation Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951 18391952) Hepatic lipid content in extreme obesity ( 25246029) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)
Interacting Genes		13 interacting genes: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TBK1 TPD52	26 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 CDKN2A CEP63 DTNBP1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 LY6D MAL2 RAC1 RAC2 SNX1 SOCS2 STAT3 TRIM54 USHBP1
Entrez ID		8835	23647
HPRD ID		05490	07209
Ensembl ID		ENSG00000120833	ENSG00000132254
Uniprot IDs		A0A024RBD2 O14508	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?
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