SOCS2 and EPOR

Number of citations of the paper that reports this interaction (PubMedID 11781573)
59

Data Source:
HPRD (in vitro, two hybrid)

		SOCS2	EPOR
Description		suppressor of cytokine signaling 2	erythropoietin receptor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth JAK-STAT Cascade Lactation Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Neuron Differentiation Negative Regulation Of JAK-STAT Cascade Phosphatidylinositol Phosphorylation Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951 18391952) Hepatic lipid content in extreme obesity ( 25246029) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		13 interacting genes: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TBK1 TPD52	39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		8835	2057
HPRD ID		05490	00587
Ensembl ID		ENSG00000120833	ENSG00000187266
Uniprot IDs		A0A024RBD2 O14508	P19235
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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