TMEM11 and CLN8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
4

Data Source:
BioGRID (two hybrid)

		TMEM11	CLN8
Description		transmembrane protein 11	CLN8 transmembrane ER and ERGIC protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Integral Component Of Plasma Membrane Integral Component Of Mitochondrial Inner Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Ceramide Binding
	Biological Process	Mitochondrion Organization Inner Mitochondrial Membrane Organization	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Nervous System Development Cholesterol Metabolic Process Lipid Biosynthetic Process Protein Catabolic Process Negative Regulation Of Proteolysis Ceramide Biosynthetic Process
Pathways		Cristae formation
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		9 interacting genes: BNIP3 BNIP3L CLN8 CREB3L1 FATE1 KASH5 LMNA SCMH1 SUV39H1	29 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1
Entrez ID		8834	2055
HPRD ID		12680	06383
Ensembl ID		ENSG00000178307	ENSG00000182372
Uniprot IDs		P17152	A0A024QZ57 Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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