NRP1 and PLXNA1

Number of citations of the paper that reports this interaction (PubMedID 10520994)
227

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NRP1	PLXNA1
Description		neuropilin 1	plexin A1
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Axon Growth Cone Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Neuronal Cell Body Receptor Complex Sorting Endosome Glutamatergic Synapse Integral Component Of Postsynaptic Membrane	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Actin Cytoskeleton Reorganization Regulation Of Cdc42 Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Positive Regulation Of GTPase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Positive Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Cell Adhesion Multicellular Organism Development Regulation Of Cell Shape Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neuron Projection Extension
Pathways		Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions
Drugs		Palifermin Pegaptanib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Coronary artery disease ( 29212778) Migraine ( 27322543) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)
Interacting Genes		23 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB	9 interacting genes: AKT1 FES L1CAM NRP1 NRP2 PLXNB1 RHOD RND1 SEMA6D
Entrez ID		8829	5361
HPRD ID		03642	11868
Ensembl ID		ENSG00000099250	ENSG00000114554
Uniprot IDs		A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9 Q6X907	Q9UIW2
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF
Enriched GO Terms of Interacting Partners?
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