LIN7A and KCNJ12

Number of citations of the paper that reports this interaction (PubMedID 15024025)
60

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		LIN7A	KCNJ12
Description		lin-7 homolog A, crumbs cell polarity complex component	potassium inwardly rectifying channel subfamily J member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane
	Molecular Function	Protein Binding L27 Domain Binding	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Dofetilide Yohimbine
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)	Body mass index ( 28892062 25673413) Height ( 20881960 31562340) Waist-hip ratio ( 25673412)
Interacting Genes		19 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK DLG2 DLG3 DLG4 DNAJC5 FAM9B GOLGA2 GRIN2B KCNJ12 MPP3 MPP5 MPP6 NOTCH2NLA SLC6A12 ZYX	16 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		8825	3768
HPRD ID		04542	09083
Ensembl ID		ENSG00000111052	ENSG00000184185
Uniprot IDs		O14910	Q14500
PDB IDs
Enriched GO Terms of Interacting Partners?
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