KCNJ12 and DTNA

Number of citations of the paper that reports this interaction (PubMedID 15024025)
60

Data Source:
HPRD (in vivo, in vitro)

		KCNJ12	DTNA
Description		potassium inwardly rectifying channel subfamily J member 12	dystrobrevin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane	Cytoplasm Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding	Protein Binding Zinc Ion Binding PDZ Domain Binding
	Biological Process	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Dofetilide Yohimbine
Diseases
GWAS		Body mass index ( 28892062 25673413) Height ( 20881960 31562340) Waist-hip ratio ( 25673412)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Urate levels in overweight individuals ( 25811787)
Interacting Genes		16 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	16 interacting genes: ACTA1 DMD DRP2 DTNBP1 GFI1B HMG20A KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN
Entrez ID		3768	1837
HPRD ID		09083	03141
Ensembl ID		ENSG00000184185	ENSG00000134769
Uniprot IDs		Q14500	A0A024RC32 B7Z3X3 Q9Y4J8
PDB IDs			2E5R
Enriched GO Terms of Interacting Partners?
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