DPM1 and DPM2

Number of citations of the paper that reports this interaction (PubMedID 10835346)
44

Data Source:
HPRD (in vivo)

		DPM1	DPM2
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Protein Mannosylation Protein O-linked Mannosylation	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		5 interacting genes: DPM2 DPM3 MTNR1A TDO2 ZBTB16	6 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1
Entrez ID		8813	8818
HPRD ID		04613	16028
Ensembl ID		ENSG00000000419	ENSG00000136908
Uniprot IDs		A0A0S2Z4Y5 O60762 Q5QPK2	O94777
PDB IDs
Enriched GO Terms of Interacting Partners?
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