RIOK3 and CASP10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RIOK3	CASP10
Description		RIO kinase 3	caspase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Preribosome, Small Subunit Precursor	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Caspase Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Protein Phosphorylation Chromosome Segregation Maturation Of SSU-rRNA Negative Regulation Of Protein Complex Assembly Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To DsRNA Cellular Response To Virus Cellular Response To DsDNA	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831)
Interacting Genes		8 interacting genes: BCL2L11 CASP10 CDC42 CREB3L3 FBXO25 PAK2 SMURF1 UBC	32 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP
Entrez ID		8780	843
HPRD ID		04659	03458
Ensembl ID		ENSG00000101782	ENSG00000003400
Uniprot IDs		B0YJ89 B4E1Q4 O14730	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs
Enriched GO Terms of Interacting Partners?
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