ACTN2 and SELE

Number of citations of the paper that reports this interaction (PubMedID 8609175)
31

Data Source:
HPRD (in vitro)

		ACTN2	SELE
Description		actinin alpha 2	selectin E
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Cell surface interactions at the vascular wall
Drugs			Carvedilol N-acetyl-alpha-neuraminic acid
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919)
Interacting Genes		86 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKAP8L ANG ANGPTL7 ATP5MC1 ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CD27 CLEC4D COIL CRABP2 CRADD DISC1 DLG1 DLG4 EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MRPL10 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB QARS1 RACK1 RAVER1 RPL35 RTP5 SAXO1 SELE SNAI1 SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 TCTEX1D2 TNN TOLLIP TTN UTRN ZC2HC1C ZNF446 ZNRD2	14 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL
Entrez ID		88	6401
HPRD ID		00019	00566
Ensembl ID		ENSG00000077522	ENSG00000007908
Uniprot IDs		F6THM6 P35609 Q59FD9	P16581
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B	1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?