CBR1 and ERCC8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		CBR1	ERCC8
Description		carbonyl reductase 1	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome Extracellular Vesicle	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein-containing Complex Binding
	Biological Process	Drug Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process Oxidation-reduction Process	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Response To Organic Cyclic Compound DNA Duplex Unwinding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Repair Protein Autoubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs		Rutin Resveratrol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		6 interacting genes: EGFR ERCC8 PRKAR2B PTPRF UBC VHL	11 interacting genes: CAMK2D CBR1 CSNK2B CUL4A DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2
Entrez ID		873	1161
HPRD ID		00267	07523
Ensembl ID		ENSG00000159228	ENSG00000049167
Uniprot IDs		A0A384NL53 P16152	A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D	4A11 6FCV
Enriched GO Terms of Interacting Partners?
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