BECN1 and KDELR2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BECN1	KDELR2
Description		beclin 1	KDEL endoplasmic reticulum protein retention receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cell Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Extrinsic Component Of Membrane Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol 3-kinase Binding GTPase Binding	KDEL Sequence Binding ER Retention Sequence Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Mitotic Metaphase Plate Congression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Protein Localization By The Cvt Pathway Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Cell Division Defense Response To Virus Negative Regulation Of Cell Death Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Retention In ER Lumen ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport
Pathways		Macroautophagy Ub-specific processing proteases	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Estradiol
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Blood protein levels ( 29875488) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 27863252) Mean platelet volume ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		50 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 ITCH KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 NF2 PDGFRA PGK1 RACK1 RAF1 SHD SMAD2 STK11 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1	22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2
Entrez ID		8678	11014
HPRD ID		05087	06598
Ensembl ID		ENSG00000126581	ENSG00000136240
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	A0A024QZT7 P33947
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK
Enriched GO Terms of Interacting Partners?
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