KHSRP and A1CF

Number of citations of the paper that reports this interaction (PubMedID 10781591)
59

Data Source:
HPRD (in vitro)

		KHSRP	A1CF
Description		KH-type splicing regulatory protein	APOBEC1 complementation factor
Image
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus Regulation Of MiRNA Metabolic Process	MRNA Processing Cytidine To Uridine Editing MRNA Modification Protein Stabilization
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Resveratrol Artenimol
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		15 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GCC1 GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I	9 interacting genes: APOBEC1 CAVIN2 CELF2 FHL3 KHSRP REL SYNCRIP TNPO2 TRAF1
Entrez ID		8570	29974
HPRD ID		10350	10627
Ensembl ID		ENSG00000088247	ENSG00000148584
Uniprot IDs		Q92945	A0A024QZI9 A0A024QZJ5 A0A024QZM7 B4E1E3 F8W9F8 Q9NQ94
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2CPD
Enriched GO Terms of Interacting Partners?
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