CAV1 and ERBB2

Number of citations of the paper that reports this interaction (PubMedID 9685399)
51

Data Source:
HPRD (in vitro, in vivo)

		CAV1	ERBB2
Description		caveolin 1	erb-b2 receptor tyrosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Cell Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane ERBB3:ERBB2 Complex Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Patched Binding Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Binding, Bridging Identical Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein Heterodimerization Activity Rac GTPase Binding Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Lipid Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Protein Localization Response To Bacterium Positive Regulation Of Calcium Ion Transport Into Cytosol Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Positive Regulation Of Peptidase Activity Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Insulin Receptor Internalization Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Pinocytosis Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Exogenous DsRNA Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Angiotensin-activated Signaling Pathway Involved In Heart Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Negative Regulation Of Inward Rectifier Potassium Channel Activity Beta-catenin Destruction Complex Disassembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Intracellular Signal Transduction ERBB2 Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Motility
Pathways		Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes	Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs			Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib Pertuzumab Afatinib Tucatinib Tesevatinib Brigatinib
Diseases		Congenital generalized lipodystrophy (CGL)	Choriocarcinoma Pancreatic cancer Gastric cancer Bladder cancer Endometrial Cancer Ovarian cancer Cholangiocarcinoma Breast cancer Cervical cancer
GWAS		Atrial fibrillation ( 28416822 30061737 29892015 22544366) Electrocardiographic traits ( 20062063 25055868) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 25173105 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Intraocular pressure ( 29617998 25173106 28073927 29235454) Ischemic stroke (cardioembolic) ( 29531354) P wave duration ( 28794112) PR interval ( 30679814 29127183 30046033 20062060 25035420 23139255) PR segment ( 24850809) QRS duration ( 30012220) QT interval ( 24952745) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Adult asthma ( 30787307) Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)
Interacting Genes		84 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VAV2	208 interacting genes: ABCB5 ABL1 ABL2 ACP3 ADGRB1 AKT1 ALK ANKS1A ANKS1B ANXA6 APBB1 APBB3 ARNT ATP6AP1 AURKA BCAR3 BECN1 BLK BLNK BMX BTC CALM1 CAV1 CBLC CCND2 CD44 CD82 CDK4 CDK6 CDKN2B CDKN2C CHN1 CISH CLCN6 CLNK CRK CRKL CTNNB1 CXCL8 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHB1 EPHB2 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERRFI1 ESR1 FBXO7 FER FGFR1 FGFR2 FGFR3 FGFR4 FGR FLT3 FLT4 FZR1 GAB1 GLCE GLIS2 GMPR2 GRB2 GRB7 GRM1 HDAC6 HDLBP HGF HLA-A HRAS HSP90AA1 HSP90B1 IARS1 IGF1R IL13RA2 IL6ST ILKAP INSR INSRR IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP KDELR2 KLK5 LATS2 LYPD3 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MERTK MET MST1R MTCH1 MUC1 MUC4 MUCL1 MYC NAT2 NCK2 NF2 NRG1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 POLD2 PPM1A PPM1F PRDM14 PSAP PSMC3IP PSMD3 PTK2 PTK2B PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAF1 RASA1 RASSF1 RET RHOBTB2 RIN1 RIN2 ROR2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT3 STK11 STK24 STUB1 STYK1 STYX SUPT6H SYK TCEAL2 TEC TGFA THRSP TLN1 TNS2 TNS3 TOB1 TP53 TTC9B TTYH2 TXK TYRO3 UBB USP2 UTP18 VAV1 VAV2 VAV3
Entrez ID		857	2064
HPRD ID		03028	01281
Ensembl ID		ENSG00000105974	ENSG00000141736
Uniprot IDs		A0A024R757 A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3	F5H1T4 J3QLU9 P04626 X5DNK3
PDB IDs			1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6OGE
Enriched GO Terms of Interacting Partners?
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