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ERBB2 and PTPN6
Number of citations of the paper that reports this interaction (PubMedID
28065597
)
26
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
ERBB2
PTPN6
Description
erb-b2 receptor tyrosine kinase 2
protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations
Cellular Component
Nucleus
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
ERBB3:ERBB2 Complex
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Phosphotyrosine Residue Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Positive Regulation Of Cell Proliferation
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Kinase B Signaling
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Cell Motility
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Cytokine Stimulus
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
GPVI-mediated activation cascade
Regulation of KIT signaling
PECAM1 interactions
Costimulation by the CD28 family
PD-1 signaling
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Brigatinib
Diseases
Choriocarcinoma
Pancreatic cancer
Gastric cancer
Bladder cancer
Endometrial Cancer
Ovarian cancer
Cholangiocarcinoma
Breast cancer
Cervical cancer
GWAS
Adult asthma (
30787307
)
Asthma (
31619474
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Interacting Genes
208 interacting genes:
ABCB5
ABL1
ABL2
ACP3
ADGRB1
AKT1
ALK
ANKS1A
ANKS1B
ANXA6
APBB1
APBB3
ARNT
ATP6AP1
AURKA
BCAR3
BECN1
BLK
BLNK
BMX
BTC
CALM1
CAV1
CBLC
CCND2
CD44
CD82
CDK4
CDK6
CDKN2B
CDKN2C
CHN1
CISH
CLCN6
CLNK
CRK
CRKL
CTNNB1
CXCL8
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHB1
EPHB2
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERRFI1
ESR1
FBXO7
FER
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FLT3
FLT4
FZR1
GAB1
GLCE
GLIS2
GMPR2
GRB2
GRB7
GRM1
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSP90AA1
HSP90B1
IARS1
IGF1R
IL13RA2
IL6ST
ILKAP
INSR
INSRR
IRS1
IRS4
ITGA5
ITGB4
ITK
JAK1
JAK2
JUP
KDELR2
KLK5
LATS2
LYPD3
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MERTK
MET
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
NAT2
NCK2
NF2
NRG1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PLCG1
POLD2
PPM1A
PPM1F
PRDM14
PSAP
PSMC3IP
PSMD3
PTK2
PTK2B
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAF1
RASA1
RASSF1
RET
RHOBTB2
RIN1
RIN2
ROR2
SERPINA3
SH2B2
SH2B3
SH2D1B
SH2D2A
SH2D3A
SH2D5
SH3BGRL3
SH3BP2
SHC1
SHC2
SHC3
SLA
SLA2
SOCS1
SOS1
SRC
SRPK1
STAT3
STK11
STK24
STUB1
STYK1
STYX
SUPT6H
SYK
TCEAL2
TEC
TGFA
THRSP
TLN1
TNS2
TNS3
TOB1
TP53
TTC9B
TTYH2
TXK
TYRO3
UBB
USP2
UTP18
VAV1
VAV2
VAV3
114 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
2064
5777
HPRD ID
01281
01475
Ensembl ID
ENSG00000141736
ENSG00000111679
Uniprot IDs
F5H1T4
J3QLU9
P04626
X5DNK3
P29350
Q53XS4
PDB IDs
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6OGE
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
Enriched GO Terms of Interacting Partners
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