LGR5 and RSPO2

Number of citations of the paper that reports this interaction (PubMedID 29769720)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LGR5	RSPO2
Description		leucine rich repeat containing G protein-coupled receptor 5	R-spondin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Trans-Golgi Network Membrane	Extracellular Region Cell Surface
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity	Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Hair Follicle Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Hormone-mediated Signaling Pathway Oocyte Differentiation Regulation Of Cell Proliferation Inner Ear Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Type 2 diabetes ( 22885922 18372903 29358691 30297969 20581827)	Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		2 interacting genes: REEP5 RSPO2	11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3
Entrez ID		8549	340419
HPRD ID		05979	17536
Ensembl ID		ENSG00000139292	ENSG00000147655
Uniprot IDs		A0A0A8K8C7 O75473	B3KVP3 Q6UXX9
PDB IDs		4BSR 4BSS 4BST 4BSU 4KNG 4UFR 4UFS
Enriched GO Terms of Interacting Partners?
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