RSPO2 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RSPO2	PLEKHF2
Description		R-spondin 2	pleckstrin homology and FYVE domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding	Protein Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Transport
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)	Radiation response ( 20923822)
Interacting Genes		11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3	71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398
Entrez ID		340419	79666
HPRD ID		17536	15147
Ensembl ID		ENSG00000147655	ENSG00000175895
Uniprot IDs		B3KVP3 Q6UXX9	Q9H8W4
PDB IDs
Enriched GO Terms of Interacting Partners?
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