SHANK3 and DLGAP3

Number of citations of the paper that reports this interaction (PubMedID 10527873)
58

Data Source:
BioGRID (two hybrid)

		SHANK3	DLGAP3
Description		SH3 and multiple ankyrin repeat domains 3	DLG associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Ionotropic Glutamate Receptor Complex Postsynaptic Density Cell Junction Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Postsynaptic Density Cell Junction Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding Protein Self-association Scaffold Protein Binding	Amyloid-beta Binding Protein Binding
	Biological Process	MAPK Cascade Axon Guidance Synapse Assembly Behavior Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Signaling Modification Of Synaptic Structure
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Intelligence (MTAG) ( 29326435) Memory dysfunction in frontotemporal lobe dementia ( 29724592)	Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence ( 28440896)
Interacting Genes		17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8	8 interacting genes: DLG1 DLG3 DLG4 DLGAP1 PTK2 PTK2B SHANK2 SHANK3
Entrez ID		85358	58512
HPRD ID		18979	18935
Ensembl ID		ENSG00000251322	ENSG00000116544
Uniprot IDs			O95886
PDB IDs
Enriched GO Terms of Interacting Partners?
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