MAP4K3 and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		MAP4K3	SH3RF1
Description		mitogen-activated protein kinase kinase kinase kinase 3	SH3 domain containing ring finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation JNK Cascade Regulation Of Mitotic Cell Cycle Response To UV Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Response To Tumor Necrosis Factor Intracellular Signal Transduction	Neuron Migration Apoptotic Process Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bone mineral density ( 31790847)	Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		7 interacting genes: BIN1 COPS5 GRB2 ITSN2 SH3GL2 SH3RF1 SORBS1	19 interacting genes: ADAM15 AKT1 AKT2 HERPUD1 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N
Entrez ID		8491	57630
HPRD ID		05373	15335
Ensembl ID		ENSG00000011566	ENSG00000154447
Uniprot IDs		A8K602 B3KMM5 Q8IVH8	Q7Z6J0
PDB IDs		5J5T
Enriched GO Terms of Interacting Partners?
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