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SH3RF1 and AKT2
Number of citations of the paper that reports this interaction (PubMedID
14504284
)
24
Data Source:
HPRD
(two hybrid, in vitro)
SH3RF1
AKT2
Description
SH3 domain containing ring finger 1
AKT serine/threonine kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Lamellipodium
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Ruffle Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Molecular Function
MAP-kinase Scaffold Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Neuron Migration
Apoptotic Process
Viral Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of JNK Cascade
Protein Autoubiquitination
Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Cellular Protein Modification Process
Signal Transduction
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Carbohydrate Transport
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Peptidyl-serine Phosphorylation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Mammary Gland Epithelial Cell Differentiation
Intracellular Protein Transmembrane Transport
Regulation Of Cell Cycle Arrest
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Activation Of GTPase Activity
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cell Motility
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Ovarian cancer
GWAS
Alzheimer disease and age of onset (
26830138
)
Body fat mass (
28552196
)
Body mass index (
28552196
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Night sleep phenotypes (
27126917
)
Photic sneeze reflex (
27182965
)
Schizophrenia (
30285260
)
Weight (
28552196
)
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Interacting Genes
19 interacting genes:
ADAM15
AKT1
AKT2
HERPUD1
KCNJ1
MAP3K10
MAP3K11
MAP3K12
MAP3K9
MAP4K3
PAK2
PDCD6IP
RAC1
RACGAP1
SEMA6A
SIAH1
UBE2D1
UBE2D3
UBE2N
40 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MTCP1
NAMPT
PDPK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
SH3RF1
SLC2A4
SNX27
SORBS2
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
Entrez ID
57630
208
HPRD ID
15335
01262
Ensembl ID
ENSG00000154447
ENSG00000105221
Uniprot IDs
Q7Z6J0
B4DG79
P31751
PDB IDs
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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