GINS4 and POLE

Number of citations of the paper that reports this interaction (PubMedID 21705323)
37

Data Source:
BioGRID (pull down)

		GINS4	POLE
Description		GINS complex subunit 4	DNA polymerase epsilon, catalytic subunit
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Protein Binding 3'-5' DNA Helicase Activity	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Unwinding of DNA Unwinding of DNA	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS			Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1	12 interacting genes: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 SCARB1 STK19 TOPBP1 XRCC5
Entrez ID		84296	5426
HPRD ID		11583	07177
Ensembl ID		ENSG00000147536	ENSG00000177084
Uniprot IDs		Q9BRT9	Q07864
PDB IDs		2E9X 2EHO 2Q9Q	5VBN
Enriched GO Terms of Interacting Partners?
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