GINS4 and POLD1

Number of citations of the paper that reports this interaction (PubMedID 21705323)
37

Data Source:
BioGRID (pull down)

		GINS4	POLD1
Description		GINS complex subunit 4	DNA polymerase delta 1, catalytic subunit
Image			No pdb structure
GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex	Nucleotide-excision Repair Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	Protein Binding 3'-5' DNA Helicase Activity	Nucleotide Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Cellular Response To UV DNA Damage Response, Detection Of DNA Damage DNA Replication Proofreading Fatty Acid Homeostasis DNA Biosynthetic Process
Pathways		Unwinding of DNA Unwinding of DNA	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS			Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1	18 interacting genes: ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 MCPH1 PCNA POLA1 POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5
Entrez ID		84296	5424
HPRD ID		11583	08882
Ensembl ID		ENSG00000147536	ENSG00000062822
Uniprot IDs		Q9BRT9	A0A024R4F4 A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0
PDB IDs		2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?
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