CAMKK1 and CAMK1

Number of citations of the paper that reports this interaction (PubMedID 10187789)
16

Data Source:
HPRD (in vivo)

		CAMKK1	CAMK1
Description		calcium/calmodulin dependent protein kinase kinase 1	calcium/calmodulin dependent protein kinase I
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Intracellular Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Positive Regulation Of Neuron Projection Development Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Smoking behavior ( 19247474)
Interacting Genes		9 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 PRKAA1 SGK1 YWHAG	20 interacting genes: APP ATF1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		84254	8536
HPRD ID		13000	05412
Ensembl ID		ENSG00000004660	ENSG00000134072
Uniprot IDs		J3KPJ3 Q8N5S9	B0YIY3 Q14012
PDB IDs		6CCF 6CD6	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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