PCGF6 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 11171983)
91

Data Source:
HPRD (in vitro)

		PCGF6	E2F6
Description		polycomb group ring finger 6	E2F transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition
Pathways		Transcriptional Regulation by E2F6	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)	Diisocyanate-induced asthma ( 25918132) Sudden cardiac arrest ( 21658281)
Interacting Genes		22 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 UBE2D3 UBE2U USP2 USP21	28 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		84108	1876
HPRD ID		07427	04251
Ensembl ID		ENSG00000156374	ENSG00000169016
Uniprot IDs		Q9BYE7	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs		2DJB
Enriched GO Terms of Interacting Partners?
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