FZD8 and LRP5

Number of citations of the paper that reports this interaction (PubMedID 11448771)
246

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		FZD8	LRP5
Description		frizzled class receptor 8	LDL receptor related protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Wnt-Frizzled-LRP5/6 Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Angiogenesis G Protein-coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Response To Radiation Anterior/posterior Pattern Specification Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Bone Marrow Development Positive Regulation Of DNA-binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Toxin Transport Apoptotic Process Involved In Blood Vessel Morphogenesis
Pathways		Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases			Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Osteoporosis-pseudoglioma syndrome (OPPG) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)	Bone mineral density ( 24249740 18455228) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Femoral neck section modulus ( 30888730) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monobrow ( 27182965)
Interacting Genes		7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1	9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1
Entrez ID		8325	4041
HPRD ID		05852	04616
Ensembl ID		ENSG00000177283	ENSG00000162337
Uniprot IDs		Q9H461	O75197
PDB IDs		5UN5 5UN6 6NDZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?