LRP5 and MESD

Number of citations of the paper that reports this interaction (PubMedID 12581525)
74

Data Source:
HPRD (in vivo)

		LRP5	MESD
Description		LDL receptor related protein 5	mesoderm development LRP chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Cellular_component Endoplasmic Reticulum Plasma Membrane
	Molecular Function	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Molecular_function Identical Protein Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Endocytosis Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Response To Radiation Anterior/posterior Pattern Specification Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Bone Marrow Development Positive Regulation Of DNA-binding Transcription Factor Activity Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retinal Blood Vessel Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Toxin Transport Apoptotic Process Involved In Blood Vessel Morphogenesis	Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Osteoporosis-pseudoglioma syndrome (OPPG) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1)
GWAS		Bone mineral density ( 24249740 18455228) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Femoral neck section modulus ( 30888730) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monobrow ( 27182965)
Interacting Genes		9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1	10 interacting genes: APP ATP6V1E1 BRD4 KPNB1 LRP5 MTNR1A PSMA5 RFC3 SNX5 SNX7
Entrez ID		4041	23184
HPRD ID		04616	12129
Ensembl ID		ENSG00000162337	ENSG00000117899
Uniprot IDs		O75197	Q14696
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?