CAMK1G and CDC45

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CAMK1G	CDC45
Description		calcium/calmodulin dependent protein kinase IG	cell division cycle 45
Image
GO Annotations	Cellular Component	Golgi Membrane Intracellular Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Neuron Projection	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Protein Phosphorylation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs		5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Diseases
GWAS		Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis ( 23624525) Obesity (extreme) ( 21935397)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		2 interacting genes: CDC45 PJA1	23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TOPBP1 TRAPPC3 UBC
Entrez ID		57172	8318
HPRD ID		10807	09145
Ensembl ID		ENSG00000008118	ENSG00000093009
Uniprot IDs		Q96NX5	O75419
PDB IDs		2JAM	5DGO
Enriched GO Terms of Interacting Partners?
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