KDM5C and CNOT4

Number of citations of the paper that reports this interaction (PubMedID 19346402)
55

Data Source:
BioGRID (enzymatic study)

		KDM5C	CNOT4
Description		lysine demethylase 5C	CCR4-NOT transcription complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex	Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Dioxygenase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Chromatin Remodeling Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination
Pathways		HDMs demethylate histones	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Numerical cognitive ability ( 31620175)
Interacting Genes		3 interacting genes: CALM1 CNOT4 H3C15	18 interacting genes: CNOT1 CNOT2 CNOT3 CNOT6 CNOT8 CNOT9 EP300 KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		8242	4850
HPRD ID		02442	05369
Ensembl ID		ENSG00000126012	ENSG00000080802
Uniprot IDs		P41229	A0A024R776 A0A024R781 A0A024R785 O95628
PDB IDs		2JRZ 5FWJ	1E4U 1UR6
Enriched GO Terms of Interacting Partners?
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