NRIP1 and AHR

Number of citations of the paper that reports this interaction (PubMedID 10428779)
35

Data Source:
HPRD (in vitro, in vivo)

		NRIP1	AHR
Description		nuclear receptor interacting protein 1	aryl hydrocarbon receptor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Protein-containing Complex Cytosolic Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Retinoid X Receptor Binding Androgen Receptor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Enhancer Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Circadian Rhythm Lipid Storage Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression CAMP-mediated Signaling Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		SUMOylation of transcription cofactors Circadian Clock Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE	Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-Monoxime Resveratrol Quercetin beta-Naphthoflavone Emodin BENZOTHIAZOLE Diosmin Indigotindisulfonic Acid Kynurenic Acid Epigallocatechin Gallate Cantharidin Indirubin
Diseases
GWAS		Alcohol dependence ( 26365420) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163) Breast cancer ( 29059683 23535729) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet distribution width ( 27863252) Pulse pressure ( 27841878) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood metabolite levels ( 24816252) Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption ( 31345160 21357676 29367735 31046077 25288136) Coffee consumption (cups per day) ( 25288136) Cutaneous squamous cell carcinoma ( 27424798) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 26192919) Lung cancer in ever smokers ( 28604730) Metabolic traits ( 21886157) Microalbuminuria ( 31511532) Plasma kynurenine levels in major depressive disorder ( 29317604) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Sweet beverage consumption ( 31046077) Tea consumption ( 31046077) Ulcerative colitis ( 26192919) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		53 interacting genes: ACTN2 AGR2 AHR APP AR ARPC3 BRCA1 CCDC85B CDK8 CEP70 CIB1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B E2F1 ESR1 ESR2 ESRRA ESRRB ESRRG HDAC1 HDAC2 HDAC3 HDAC5 HNF4A JUN KAT2B LDOC1 MAP3K7 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 PPARA PPARD PPARG PRMT1 RARA RORB RXRA RXRB TEX11 THRA THRB TNFRSF14 TRAF2 VDR YWHAH	35 interacting genes: AIP AR ARNT ARNT2 ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		8204	196
HPRD ID		03927	02596
Ensembl ID		ENSG00000180530	ENSG00000106546
Uniprot IDs		A8K171 P48552	A0A024R9Z8 P35869
PDB IDs		2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07	5NJ8
Enriched GO Terms of Interacting Partners?
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