SYMPK and TOP1

  • Number of citations of the paper that reports this interaction (PubMedID 12549820)
  • 3
  • Data Source:
  • BioGRID (unspecified method)

SYMPK

TOP1

Description symplekin DNA topoisomerase I
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
  • Colon cancer ( 28295283)
  • Colorectal cancer ( 28295283)
  • Coronary artery disease ( 29212778)
  • Eosinophil counts ( 27863252)
  • Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309)
  • Antipsychotic drug-induced weight gain in schizophrenia ( 31447353)
  • Cholesterol, total ( 24097068 20686565)
  • LDL cholesterol ( 24097068 20686565)
  • LDL cholesterol levels ( 28334899)
  • LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Male-pattern baldness ( 28196072)
  • Metabolite levels ( 23823483)
  • Total cholesterol levels ( 28334899)
  • Urate levels ( 31578528)
Interacting Genes 7 interacting genes: CSTF2 HSF1 HTT RIN3 TOP1 UBE2I YBX3 59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6
Entrez ID 8189 7150
HPRD ID 09090 00535
Ensembl ID ENSG00000125755 ENSG00000198900
Uniprot IDs A0A024R0R6 Q92797 P11387 Q9BVT2
PDB IDs 3O2Q 3O2S 3O2T 3ODR 3ODS 4H3H 4H3K 1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?
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