MAP1LC3B and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAP1LC3B	RAP1GAP
Description		microtubule associated protein 1 light chain 3 beta	RAP1 GTPase activating protein
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GO Annotations	Cellular Component	Autophagosome Membrane Intracellular Mitochondrion Autophagosome Cytosol Microtubule Axoneme Endomembrane System Organelle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Golgi Membrane Cytosol Membrane
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Microvillus Assembly
Pathways		Macroautophagy Pink/Parkin Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy	Rap1 signalling RET signaling
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		65 interacting genes: AAMP ADD1 ADNP AMBRA1 ANK2 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA CUL3 DBI DBN1 DNMT3B EED EPS8 EVA1A FLCN FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NBR1 NEDD4 RAD1 RAP1GAP RB1CC1 RETREG2 RIPOR1 RPLP1 SAFB SEM1 SMARCB1 SNU13 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B TBK1 THAP7 TMOD3 TNIP1 TRIM21 ULK1 UPF2 VHL	15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12
Entrez ID		81631	5909
HPRD ID		14358	02609
Ensembl ID		ENSG00000140941	ENSG00000076864
Uniprot IDs		Q658J6 Q9GZQ8	A0A024RAB5 P47736 X6R8W7
PDB IDs		1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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