MAP1LC3B and FLCN

Number of citations of the paper that reports this interaction (PubMedID 25126726)
27

Data Source:
BioGRID (pull down)

		MAP1LC3B	FLCN
Description		microtubule associated protein 1 light chain 3 beta	folliculin
Image
GO Annotations	Cellular Component	Autophagosome Membrane Intracellular Mitochondrion Autophagosome Cytosol Microtubule Axoneme Endomembrane System Organelle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Respiration Negative Regulation Of Mitochondrial DNA Metabolic Process Negative Regulation Of Muscle Tissue Development Negative Regulation Of Post-translational Protein Modification Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy Pink/Parkin Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy	Amino acids regulate mTORC1
Drugs
Diseases			Renal cell carcinoma Birt-Hogg-Dube syndrome
GWAS		General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261)	Heel bone mineral density ( 30598549)
Interacting Genes		65 interacting genes: AAMP ADD1 ADNP AMBRA1 ANK2 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA CUL3 DBI DBN1 DNMT3B EED EPS8 EVA1A FLCN FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NBR1 NEDD4 RAD1 RAP1GAP RB1CC1 RETREG2 RIPOR1 RPLP1 SAFB SEM1 SMARCB1 SNU13 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B TBK1 THAP7 TMOD3 TNIP1 TRIM21 ULK1 UPF2 VHL	4 interacting genes: APP GABARAP HSP90AA1 MAP1LC3B
Entrez ID		81631	201163
HPRD ID		14358	06278
Ensembl ID		ENSG00000140941	ENSG00000154803
Uniprot IDs		Q658J6 Q9GZQ8	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04	3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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