TRIM8 and RC3H2

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		TRIM8	RC3H2
Description		tripartite motif containing 8	ring finger and CCCH-type domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol PML Body	P-body Cell Surface Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding Ubiquitin-protein Transferase Activity RNA Stem-loop Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell	Protein Polyubiquitination B Cell Homeostasis Regulation Of Transcription By RNA Polymerase II Post-embryonic Development Posttranscriptional Regulation Of Gene Expression Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971)
Interacting Genes		46 interacting genes: BRAP CBL CCNH ITSN1 MAGEC2 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	14 interacting genes: KLHL6 TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2
Entrez ID		81603	54542
HPRD ID		06934	14726
Ensembl ID		ENSG00000171206	ENSG00000056586
Uniprot IDs		Q9BZR9	A0A024R899 Q9HBD1
PDB IDs			4Z30 4Z31 4ZLC 4ZLD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?