RC3H2 and UBE2E3

Number of citations of the paper that reports this interaction (PubMedID 26489670)
7

Data Source:
BioGRID (pull down)

		RC3H2	UBE2E3
Description		ring finger and CCCH-type domains 2	ubiquitin conjugating enzyme E2 E3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cell Surface Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding Ubiquitin-protein Transferase Activity RNA Stem-loop Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination B Cell Homeostasis Regulation Of Transcription By RNA Polymerase II Post-embryonic Development Posttranscriptional Regulation Of Gene Expression Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Ankylosing spondylitis ( 23749187) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: KLHL6 TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2	84 interacting genes: ACVR1 ARID3A ARIH2 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WWP2 ZNF746 ZNRF1 ZNRF4
Entrez ID		54542	10477
HPRD ID		14726	05000
Ensembl ID		ENSG00000056586	ENSG00000170035
Uniprot IDs		A0A024R899 Q9HBD1	Q969T4 R4GNG6
PDB IDs		4Z30 4Z31 4ZLC 4ZLD
Enriched GO Terms of Interacting Partners?
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