PNPLA3 and SNX27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PNPLA3	SNX27
Description		patatin like phospholipase domain containing 3	sorting nexin 27
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane Integral Component Of Membrane	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling Lipid Homeostasis	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 30718733 31219225) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 31219225 29403010) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880) HDL cholesterol ( 30275531) Hematocrit ( 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin concentration ( 27863252) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010) Metabolite levels ( 21909109) Non-alcoholic fatty liver disease activity score ( 31311600) Nonalcoholic fatty liver disease ( 21423719 22719876 29271184 29385134 31311600) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 27863252 28957414) Serum uric acid levels ( 30993211) Total cholesterol levels ( 31217584 30275531) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)	Body mass index ( 26426971)
Interacting Genes		3 interacting genes: AKT2 LINC00839 SNX27	10 interacting genes: AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SLC2A1 VPS26A
Entrez ID		80339	81609
HPRD ID		12430	11591
Ensembl ID		ENSG00000100344	ENSG00000143376
Uniprot IDs		Q9NST1	A0A2R8Y8A7 Q96L92
PDB IDs			4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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