PNPLA3

Description		patatin like phospholipase domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane Integral Component Of Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling Lipid Homeostasis
Pathways		Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 30718733 31219225) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 31219225 29403010) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880) HDL cholesterol ( 30275531) Hematocrit ( 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin concentration ( 27863252) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010) Metabolite levels ( 21909109) Non-alcoholic fatty liver disease activity score ( 31311600) Nonalcoholic fatty liver disease ( 21423719 22719876 29271184 29385134 31311600) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 27863252 28957414) Serum uric acid levels ( 30993211) Total cholesterol levels ( 31217584 30275531) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: AKT2 LINC00839 SNX27
Entrez ID		80339
HPRD ID		12430
Ensembl ID		ENSG00000100344
Uniprot IDs		Q9NST1
PDB IDs
Enriched GO Terms of Interacting Partners?
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