NUP214 and MRPS6

		NUP214	MRPS6
Description		nucleoporin 214	mitochondrial ribosomal protein S6
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GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Small Ribosomal Subunit
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Structural Constituent Of Ribosome Protein Binding Small Ribosomal Subunit RRNA Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Translation Mitochondrial Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	Coronary heart disease ( 21378990) Joint mobility (Beighton score) ( 27182965) Myocardial infarction (early onset) ( 19198609)
Interacting Genes		29 interacting genes: APC ASS1 CHST6 CLEC4G DDX19B DYNC1I1 IPO5 LSS MRPS6 NCBP1 NUP107 NUP42 NUP62 NUP88 NUP98 NXF1 NXF2 POMT1 PRRX2 SMAD2 SMAD3 SMAD4 STOM TNPO1 VAV2 XPO1 XPO5 XPOT ZFP36	9 interacting genes: APP CEP126 LRIF1 MKRN3 NUP214 RNF181 SREBF2 SRPK2 STAT5A
Entrez ID		8021	64968
HPRD ID		00258	11374
Ensembl ID		ENSG00000126883	ENSG00000243927
Uniprot IDs		B7ZAV2 P35658	P82932
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS	3J9M 6NU2 6NU3
Enriched GO Terms of Interacting Partners?
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