CEP76 and MLH1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
3

Data Source:
BioGRID (two hybrid)

		CEP76	MLH1
Description		centrosomal protein 76	mutL homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Protein-containing Complex	Synaptonemal Complex Male Germ Cell Nucleus Cell Nucleus Nucleoplasm Chiasma Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)
Interacting Genes		55 interacting genes: AKAP7 AKT1 BANP C22orf39 CABP5 CAPN3 CCDC92 CCNK CIR1 COIL CRYBA4 CSNK1G1 CUTC DCTD DZIP1L EAF1 EP400P1 FAM90A1 GDAP2 GFAP HSPB7 ILVBL KIAA1143 KIFBP KLHDC4 LATS1 MAGEA11 MBD3 MLH1 NHLRC2 NME5 PAICS PARD6B PIN1 PLCB1 POM121 RADIL RNF128 RPL9 SALL2 SH2D4A SINHCAF STK26 TBC1D27P THRA TOB2 TSPOAP1 TSSC4 TTC21A TUFT1 TXNDC9 WDFY3 ZBTB24 ZMAT2 ZNF85	84 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CBY2 CCDC33 CDCA7L CEP126 CEP76 CKAP4 CKB DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GPX1 GSTP1 IGKC KPNA2 LGALS4 LY96 MAGEA8 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RADX RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SQSTM1 STAP2 TASOR2 TLE5 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZBED1 ZC3H11A ZER1
Entrez ID		79959	4292
HPRD ID		12694	00390
Ensembl ID		ENSG00000101624	ENSG00000076242
Uniprot IDs		B4DP81 Q8TAP6	A0A024R2S9 P40692 Q59EG3
PDB IDs			3RBN 4P7A 5U5P
Enriched GO Terms of Interacting Partners?
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