MLH1 and ARAF

Number of citations of the paper that reports this interaction (PubMedID 20706999)
7

Data Source:
BioGRID (two hybrid)

		MLH1	ARAF
Description		mutL homolog 1	A-Raf proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Cell Nucleus Nucleoplasm Chiasma Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex	Cellular_component Mitochondrion Cytosol
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly	MAPK Cascade Cellular Protein Modification Process Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			ATP
Diseases		Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)
Interacting Genes		84 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CBY2 CCDC33 CDCA7L CEP126 CEP76 CKAP4 CKB DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GPX1 GSTP1 IGKC KPNA2 LGALS4 LY96 MAGEA8 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RADX RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SQSTM1 STAP2 TASOR2 TLE5 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZBED1 ZC3H11A ZER1	59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG YWHAZ
Entrez ID		4292	369
HPRD ID		00390	02405
Ensembl ID		ENSG00000076242	ENSG00000078061
Uniprot IDs		A0A024R2S9 P40692 Q59EG3	A0A024R178 P10398 Q96II5
PDB IDs		3RBN 4P7A 5U5P	1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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