EHMT1 and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		EHMT1	LZTR1
Description		euchromatic histone lysine methyltransferase 1	leucine zipper like transcription regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Body	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane
	Molecular Function	P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding	DNA-binding Transcription Factor Activity Ras GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Histone H3-K9 Methylation Response To Fungicide Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 TP53 TRIM15 WIZ	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		79813	8216
HPRD ID		07383	08992
Ensembl ID		ENSG00000181090	ENSG00000099949
Uniprot IDs		A0A1B0GV09 Q9H9B1	A0A384NL67 Q8N653
PDB IDs		2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP
Enriched GO Terms of Interacting Partners?
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