SAP30L and HMBOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SAP30L	HMBOX1
Description		SAP30 like	homeobox containing 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleoplasm Nucleolus	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Phosphatidylinositol-5-phosphate Binding Nucleosome Binding Histone Binding Non-sequence-specific DNA Binding, Bending	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone Deacetylation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Telomerase Activity Positive Regulation Of Telomerase Activity
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) QRS duration ( 25035420)	Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: FEZ1 FEZ2 HMBOX1	49 interacting genes: ABITRAM AEBP2 APP ATP5PO BYSL C8orf33 CARD9 CBX8 CCNG1 DAB1 DYNLL2 ENTPD2 FAM13C FAM161A FAM74A4 FARS2 FNDC11 FRMD6 FXR2 KAT5 LNX1 MAGEH1 MFAP1 MORF4L1 MRPL11 MRPL28 PIP4K2B PKD1P1 PRKAA1 PRKAA2 RBMY2FP REEP6 RPL9 SAP30L SFR1 SH2D4A SNRPB2 TCEANC UBA6 UBE2Z VPS72 WT1 ZBTB24 ZMAT2 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		79685	79618
HPRD ID		08563	07964
Ensembl ID		ENSG00000164576	ENSG00000147421
Uniprot IDs		Q9HAJ7	D3DSU2 Q6NT76
PDB IDs		2N1U	2CUF 4J19
Enriched GO Terms of Interacting Partners?
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