PLEKHF2 and RSPO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PLEKHF2	RSPO2
Description		pleckstrin homology and FYVE domain containing 2	R-spondin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Extracellular Region Cell Surface
	Molecular Function	Protein Binding Phosphatidylinositol Binding Metal Ion Binding	Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Protein Transport	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Radiation response ( 20923822)	Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398	11 interacting genes: JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-7 KRTAP10-9 LGR4 LGR5 PLEKHF2 RNF43 SUV39H1 ZNRF3
Entrez ID		79666	340419
HPRD ID		15147	17536
Ensembl ID		ENSG00000175895	ENSG00000147655
Uniprot IDs		Q9H8W4	B3KVP3 Q6UXX9
PDB IDs
Enriched GO Terms of Interacting Partners?
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