ZYX and WNK1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		ZYX	WNK1
Description		zyxin	WNK lysine deficient protein kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Adherens Junction Focal Adhesion Phagocytic Vesicle	Cytoplasm Cytosol Membrane
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Viral Process Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Trans-phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs		Artenimol
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 28240269) White blood cell count (basophil) ( 27863252)	Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		30 interacting genes: ACTN1 ATXN1 BSPRY ENAH HIPK3 IMP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384	35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		7791	65125
HPRD ID		03592	05570
Ensembl ID		ENSG00000159840	ENSG00000060237
Uniprot IDs		Q15942 Q96AF9	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs			4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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