WNK1 and WNK2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		WNK1	WNK2
Description		WNK lysine deficient protein kinase 1	WNK lysine deficient protein kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity	Protein Serine/threonine Kinase Activity ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Trans-phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Protein Phosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Sodium Ion Transport Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Protein Autophosphorylation Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	5 interacting genes: ATXN1 ESS2 MTDH WNK1 YWHAZ
Entrez ID		65125	65268
HPRD ID		05570	06951
Ensembl ID		ENSG00000060237	ENSG00000165238
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	F8W9F9 Q9Y3S1
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK	6ELM 6FBK
Enriched GO Terms of Interacting Partners?
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